Indigenous 3D bio-printer to print human tissues

New Delhi, Nov 18Th (India Science Wire,) Bio-printing is a technique for tissue replication that supports or nurtures living cell. This technology could be an alternative to organ transplantation. It can be used to produce functional human tissues, such as skin, using biomaterials or bioinks that are engineered to print artificial living tissue.

An indigenous state-of-the-art 3D Bio-Printer ‘Mito Plus’ launched by Indian Tech Startup Avay Biosciences has been found to be helpful in printing human tissues. The Bengaluru Tech Summit, 16-18 November 2022 saw the launch of Mito Plus. The prototype of Mito Plus was placed at the Indian Institute of Science, Bangalore, which is the highest-ranked science research institution according to NIRF Rankings.

Mito Plus, a 3D bio-printer that is more advanced than the original prototype was developed using inputs from Dr Bikramjit Basu’s research lab at IISc. It was co-founded by Avay, an IIT Madras alumnus. It is among the top 3D printers in India. Avay Biosciences offers a complete range of hardware and software development to provide end-to-end Bio 3D printing solutions for India.

Manish Amin, Chief Executive Officer, Avay Biosciences, said, “MITO plus is an advanced bio-printer at its price range which can be used to print a wide range of biomaterials. The printer features an inbuilt UV curing, HEPA filter, as well as temperature control. The print-head can be cooled to 4°C and the print bed heated to 80°C. MITO plus can be used for pharmaceutical drug discovery and drug testing applications, it can also be used in cancer biology and cosmetology applications.”

Bio-printers operate in the same manner as other 3D printers. The only difference is that instead of delivering material such as metal or plastics, bioprinters deposit layers of biomaterials. These biomaterials may contain living cells. They can be used to create complex structures like skin, liver, and bone tissue. Bio-printing 3D is a wonderful gift for humanity thanks to science and technology. Many challenges remain to be overcome. ‘’There is still a long way to go before we can create fully functioning and viable organs for human transplant,” Amin explained.

“We are working on having our printers develop skin – the most common type of layered tissue that could help victims of severe burns. These tissues can also be used for toxicology screens and other testing mechanisms,” said Suhridh Sundaram, Chief Operating Officer, Avay Biosciences.

Bio-printing usually uses polymers to try to recreate extracellular matrix (ECM), which is the native material of a particular cell. It is crucial that bio-printers are affordable in order to develop artificial organs. Future research relies on these infrastructures. Bioprinting can also create artificial meat from animal cells.

Apart from premier Research and Development institutions such as IIT Madras and IISc Bangalore, the tech startup’s customers and collaborators include the Institute of Chemical Technology (ICT), Mumbai; National Institute of Pharmaceutical Education And Research (NIPER), Hyderabad; and BITS Pilani (Goa Campus). (India Science Wire).

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